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AOD-9604 is a synthetic fragment of human growth hormone (the 176-191 region), studied for fat-metabolism signaling without the full hormone's growth effects

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However, researchers should note that longer trials with ipamorelin may cause side effects typical for ghrelin mimetics, such as water retention and increased appetite [23]

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The underlying pharmacology is more subtle: the affinity ratio of the three receptors has been calibrated by Eli Lilly to maximize the metabolic effect without compromising glycemic control